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- Miscellaneous
- Metronidazole WHAT METRONIDAZOLE IS AND WHAT IT IS USED FOR This belongs to a group of medicines called antibiotics. It works by killing bacteria and parasites that cause infections in your body. It can be used to: Treat infections of the blood, brain, lung, bones, genital tract, pelvic area, stomach and intestines Treat gum ulcers and other dental infections Treat infected leg ulcers and pressure sores Prevent infections after surgery If you need any further information on your illness, speak to your doctor. BEFORE YOU TAKE METRONIDAZOLE Do not take Metronidazole and tell your doctor if: You are allergic (hypersensitive) to metronidazole, nitroimidazoles (e.g. tinidazole) or any of the other ingredients in your medicine (listed in Section 6: Further information). Signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue. Do not take Metronidazole if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before taking Metronidazole . Take special care with Metronidazole and check with your doctor or pharmacist before using your medicine if: You have or have ever had a liver problem You are having kidney dialysis (see section 3: ‘People having kidney dialysis’) You have a disease of the nervous system If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking your medicine. Do this even if they have applied in the past. Cases of severe liver toxicity/acute liver failure, including cases with a fatal outcome, in patients with Cockayne syndrome have been reported with Metronidazole . If you are affected by Cockayne syndrome, your doctor should also monitor your liver function frequently while you are being treated with Metronidazole and afterwards. Serious skin reactions including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalised exanthematous pustulosis (AGEP) have been reported with the use of Metronidazole . SJS/TEN can appear initially as reddish target-like spots or circular patches often with central blisters on the trunk. Also, ulcers of the mouth, throat, nose, genitals and eyes (red and swollen eyes) can occur. These serious skin rashes are often preceded by fever and/or flu-like symptoms. The rashes may progress to widespread peeling of the skin and life- threatening complications or be fatal. AGEP appears at the initiation of treatment as a red, scaly widespread rash with bumps under the skin and blisters accompanied by fever. The most common location: mainly localised on the skin folds, trunk, and upper extremities. The highest risk for occurrence of serious skin reactions is within one week, typically, within 48 hours after start of treatment. If you develop a serious rash or another of these skin symptoms, stop taking Metronidazole and contact your doctor or seek medical attention immediately. Tell your doctor immediately and stop taking Metronidazole if you develop: St
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